VASCULAR BIOLOGY Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms
نویسندگان
چکیده
1Hospital for Sick Children Research Institute, Developmental and Stem Cell Biology Program, Toronto; 2Mouse Imaging Centre (MICe), Hospital for Sick Children, Toronto Centre for Phenogenomics, Toronto; 3Department of Medical Biophysics, University of Toronto, Toronto; 4Toronto Centre for Phenogenomics, Toronto; 5Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto; and 6Department of Molecular Genetics, University of Toronto, Toronto, ON
منابع مشابه
Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms.
Despite the clear importance of Hedgehog (Hh) signaling in blood vascular development as shown by genetic analysis, its mechanism of action is still uncertain. To better understand the role of Hh in vascular development, we further characterized its roles in vascular development in mouse embryos and examined its interaction with vascular endothelial growth factor (VEGF), a well-known signaling ...
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OBJECTIVE Notch, VEGF, and components of the Hedgehog (Hh) signaling pathway have been implicated in vascular morphogenesis. The role of Notch in mediating hedgehog control of adult vascular smooth muscle cell (SMC) growth and survival remains unexplored. METHODS AND RESULTS In cultured SMCs, activation of Hh signaling with recombinant rShh (3.5 mug/mL) or plasmid encoded Shh increased Ptc1 e...
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تاریخ انتشار 2010